Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase

Frédéric Alvarez; Arnaud Ghérardi; Pascal Nebois; Marie Elizabeth Sarciron; Anne Françoise Pétavy; Nadia Walchshofer

doi:10.1016/s0960-894x(02)00064-1

Benzimidazole-4,7-diones as inhibitors of protozoal (Toxoplasma gondii) purine nucleoside phosphorylase

Bioorg Med Chem Lett. 2002 Mar 25;12(6):977-9. doi: 10.1016/s0960-894x(02)00064-1.

Authors

Frédéric Alvarez¹, Arnaud Ghérardi, Pascal Nebois, Marie Elizabeth Sarciron, Anne Françoise Pétavy, Nadia Walchshofer

Affiliation

¹ Laboratoire de Chimie Organique (EA 635), Faculté de Pharmacie, Université Lyon I, 8, Avenue Rockefeller, 69373 Lyon Cedex 08, France.

PMID: 11959007
DOI: 10.1016/s0960-894x(02)00064-1

Abstract

Benzimidazole-4,7-diones derivatives substituted at 1- and/or 2-position have been synthetized and tested as inhibitors of purine nucleoside phosphorylase (PNP), isolated from two strains of Toxoplasma gondii (RH and ME 49). They were identified as inhibitors of both enzymes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / chemical synthesis*
Antiprotozoal Agents / pharmacology
Benzimidazoles / chemical synthesis
Benzimidazoles / pharmacology*
Dose-Response Relationship, Drug
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / pharmacology
Purine-Nucleoside Phosphorylase / antagonists & inhibitors*
Structure-Activity Relationship
Toxoplasma / enzymology*

Substances

Antiprotozoal Agents
Benzimidazoles
Enzyme Inhibitors
Purine-Nucleoside Phosphorylase